According to a research, women are more likely to suffer from Asthma post puberty. The absence of testosterone is the reason. If research is to be believed then it will open altogether a new way to treat the lung conditions among women.
This research was carried out in France, it stated that primary male sex hormone does not allow to develop a type of immune cell which is responsible for Asthma rather it acts as a barrier against males developing inflammatory airway conditions.
“Our exploration demonstrates that abnormal amounts of testosterone in males ensure them against the advancement of unfavorably susceptible Asthma,” said Cyril Seillet at the Physiopathology Center of Toulouse-Purpan in France.
“We distinguished that testosterone is a powerful inhibitor of natural lymphoid cells, a recently depicted resistant cell that has been related to the start of Asthma,” Seillet said.
These natural lymphoid cells – or ILC2s – “sense” testosterone and react by ending creation of the cells.
“Testosterone specifically follows up on ILC2s by restraining their expansion. So in males, you have less ILC2s in the lungs and this specifically connects with the decreased seriousness of asthma,” Seillet said in a report distributed in the Journal of Experimental Medicine.
ILC2s are found in the lungs, skin and different organs.
These cells deliver provocative proteins that can bring about lung aggravation and harm because of normal triggers for unfavorably susceptible asthma, for example, dust, clean vermin, tobacco smoke and pet hair.
Understanding the component that drives the sex contrasts in unfavorably susceptible asthma could prompt new medicines for the illness, the analysts said.